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Structure paper

TitleDeciphering Determinants in Ribosomal Methyltransferases That Confer Antimicrobial Resistance.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 141, Page 1425-1429, Year 2019
Publish dateSep 21, 2018 (structure data deposition date)
AuthorsBhujbalrao, R. / Anand, R.
External linksJ. Am. Chem. Soc. / PubMed:30624914
MethodsX-ray diffraction
Resolution1.9 - 3.8 Å
Structure data

PDB-6ifs:
KsgA from Bacillus subtilis 168
Method: X-RAY DIFFRACTION / Resolution: 2.27 Å

PDB-6ift:
KsgA from Bacillus subtilis in complex with SAM
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-6ifv:
C-terminal truncated KsgA from Bacillus subtilis 168
Method: X-RAY DIFFRACTION / Resolution: 3.11 Å

PDB-6ifw:
crystal structure of chimeric construct of KsgA with loop 1 from erm
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

PDB-6ifx:
Crystal structure of chimeric KsgA with loop 12 from Erm
Method: X-RAY DIFFRACTION / Resolution: 3.8 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SAM:
S-ADENOSYLMETHIONINE

Source
  • bacillus subtilis (strain 168) (bacteria)
KeywordsTRANSFERASE / KsgA / Rossmann fold / resistance / SAM / methyltransferase / truncation / Chimera / erythromycin

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