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-Structure paper
Title | Binding to an Unusual Inactive Kinase Conformation by Highly Selective Inhibitors of Inositol-Requiring Enzyme 1 alpha Kinase-Endoribonuclease. |
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Journal, issue, pages | J. Med. Chem., Vol. 62, Page 2447-2465, Year 2019 |
Publish date | Oct 9, 2018 (structure data deposition date) |
Authors | Colombano, G. / Caldwell, J.J. / Matthews, T.P. / Bhatia, C. / Joshi, A. / McHardy, T. / Mok, N.Y. / Newbatt, Y. / Pickard, L. / Strover, J. ...Colombano, G. / Caldwell, J.J. / Matthews, T.P. / Bhatia, C. / Joshi, A. / McHardy, T. / Mok, N.Y. / Newbatt, Y. / Pickard, L. / Strover, J. / Hedayat, S. / Walton, M.I. / Myers, S.M. / Jones, A.M. / Saville, H. / McAndrew, C. / Burke, R. / Eccles, S.A. / Davies, F.E. / Bayliss, R. / Collins, I. |
External links | J. Med. Chem. / PubMed:30779566 |
Methods | X-ray diffraction |
Resolution | 2.14 - 2.73 Å |
Structure data | PDB-6hv0: PDB-6hx1: |
Chemicals | ChemComp-GUK: ChemComp-HOH: ChemComp-GXK: |
Source |
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Keywords | SIGNALING PROTEIN / Unfolded Protein Response Allosteric inhibitor / TRANSFERASE / IRE1 KINASE / PROTEROS BIOSTRUCTURES GMBH |