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TitlePreclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib inKRAS-Mutant Pancreatic and Colorectal Cancer.
Journal, issue, pagesCancer Res., Vol. 79, Page 2367-2378, Year 2019
Publish dateAug 28, 2018 (structure data deposition date)
AuthorsWeisner, J. / Landel, I. / Reintjes, C. / Uhlenbrock, N. / Trajkovic-Arsic, M. / Dienstbier, N. / Hardick, J. / Ladigan, S. / Lindemann, M. / Smith, S. ...Weisner, J. / Landel, I. / Reintjes, C. / Uhlenbrock, N. / Trajkovic-Arsic, M. / Dienstbier, N. / Hardick, J. / Ladigan, S. / Lindemann, M. / Smith, S. / Quambusch, L. / Scheinpflug, R. / Depta, L. / Gontla, R. / Unger, A. / Muller, H. / Baumann, M. / Schultz-Fademrecht, C. / Gunther, G. / Maghnouj, A. / Muller, M.P. / Pohl, M. / Teschendorf, C. / Wolters, H. / Viebahn, R. / Tannapfel, A. / Uhl, W. / Hengstler, J.G. / Hahn, S.A. / Siveke, J.T. / Rauh, D.
External linksCancer Res. / PubMed:30858154
MethodsX-ray diffraction
Resolution2.9 Å
Structure data

PDB-6hhf:
Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor Borussertib
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-G4K:
Borussertib

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Akt1 / borussertib / covalent-allosteric

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