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Title | Novel Quinazolinone Inhibitors of ALK2 Flip between Alternate Binding Modes: Structure-Activity Relationship, Structural Characterization, Kinase Profiling, and Cellular Proof of Concept. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 7261-7272, Year 2018 |
Publish date | May 10, 2018 (structure data deposition date) |
![]() | Hudson, L. / Mui, J. / Vazquez, S. / Carvalho, D.M. / Williams, E. / Jones, C. / Bullock, A.N. / Hoelder, S. |
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Methods | X-ray diffraction |
Resolution | 1.98 - 2.2 Å |
Structure data | ![]() PDB-6gi6: ![]() PDB-6gin: ![]() PDB-6gip: |
Chemicals | ![]() ChemComp-EZB: ![]() ChemComp-SO4: ![]() ChemComp-EDO: ![]() ChemComp-HOH: ![]() ChemComp-IR2: ![]() ChemComp-EUN: |
Source |
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![]() | SIGNALING PROTEIN / Kinase / BMP / inhibitor / signalling |