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Title | Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 4135-4154, Year 2018 |
Publish date | Jan 30, 2018 (structure data deposition date) |
![]() | Powell, J. / Mota, F. / Steadman, D. / Soudy, C. / Miyauchi, J.T. / Crosby, S. / Jarvis, A. / Reisinger, T. / Winfield, N. / Evans, G. ...Powell, J. / Mota, F. / Steadman, D. / Soudy, C. / Miyauchi, J.T. / Crosby, S. / Jarvis, A. / Reisinger, T. / Winfield, N. / Evans, G. / Finniear, A. / Yelland, T. / Chou, Y.T. / Chan, A.W.E. / O'Leary, A. / Cheng, L. / Liu, D. / Fotinou, C. / Milagre, C. / Martin, J.F. / Jia, H. / Frankel, P. / Djordjevic, S. / Tsirka, S.E. / Zachary, I.C. / Selwood, D.L. |
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Methods | X-ray diffraction |
Resolution | 0.9 - 2.811 Å |
Structure data | ![]() PDB-6fmc: ![]() PDB-6fmf: |
Chemicals | ![]() ChemComp-DUE: ![]() ChemComp-HOH: ![]() ChemComp-TFA: |
Source |
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![]() | SIGNALING PROTEIN / VEGF-receptor / Semaphorin-receptor / small molecule inhibitor / Angiogenesis / Discoidin domain / VEGF signaling / semaphorin signaling / discoiding domain |