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TitleEffects of 3-Bromo-4,5-dihydroisoxazole Derivatives on Nrf2 Activation and Heme Oxygenase-1 Expression.
Journal, issue, pagesChemistryOpen, Vol. 7, Page 858-864, Year 2018
Publish dateJan 8, 2018 (structure data deposition date)
AuthorsPinto, A. / El Ali, Z. / Moniot, S. / Tamborini, L. / Steegborn, C. / Foresti, R. / De Micheli, C.
External linksChemistryOpen / PubMed:30397576
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-6ffm:
Crystal Structure of Human KEAP1 BTB Domain in Complex with isoxazoline-based inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-D8N:
~{N}-[4-[(5~{R})-4,5-dihydro-1,2-oxazol-5-yl]phenyl]ethanamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / 3-bromo-4 5-dihydroisoxazole / BTB domain / antioxidant response

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