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-Structure paper
| Title | A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage. |
|---|---|
| Journal, issue, pages | Nat Commun, Vol. 9, Page 1107-1107, Year 2018 |
| Publish date | Oct 25, 2017 (structure data deposition date) |
 Authors | Ladds, M.J.G.W. / van Leeuwen, I.M.M. / Drummond, C.J. / Chu, S. / Healy, A.R. / Popova, G. / Pastor Fernandez, A. / Mollick, T. / Darekar, S. / Sedimbi, S.K. ...Ladds, M.J.G.W. / van Leeuwen, I.M.M. / Drummond, C.J. / Chu, S. / Healy, A.R. / Popova, G. / Pastor Fernandez, A. / Mollick, T. / Darekar, S. / Sedimbi, S.K. / Nekulova, M. / Sachweh, M.C.C. / Campbell, J. / Higgins, M. / Tuck, C. / Popa, M. / Safont, M.M. / Gelebart, P. / Fandalyuk, Z. / Thompson, A.M. / Svensson, R. / Gustavsson, A.L. / Johansson, L. / Farnegardh, K. / Yngve, U. / Saleh, A. / Haraldsson, M. / D'Hollander, A.C.A. / Franco, M. / Zhao, Y. / Hakansson, M. / Walse, B. / Larsson, K. / Peat, E.M. / Pelechano, V. / Lunec, J. / Vojtesek, B. / Carmena, M. / Earnshaw, W.C. / McCarthy, A.R. / Westwood, N.J. / Arsenian-Henriksson, M. / Lane, D.P. / Bhatia, R. / McCormack, E. / Lain, S. |
 External links | Nat Commun / PubMed:29549331 |
| Methods | X-ray diffraction |
| Resolution | 1.7 Å |
| Structure data |  PDB-6et4: |
| Chemicals |  ChemComp-FMN:  ChemComp-DOR:  ChemComp-SDV:  ChemComp-DDQ:  ChemComp-ACY:  ChemComp-GOL:  ChemComp-SO4:  ChemComp-CL:  ChemComp-HOH: |
| Source |
|
 Keywords | OXIDOREDUCTASE / DHODH / CANCER / P53 ACTIVATION / PYRIMIDINE SYNTHESIS |
homo sapiens (human)