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Structure paper

TitleCrystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.
Journal, issue, pagesBiochemistry, Vol. 57, Page 593-603, Year 2018
Publish dateJan 31, 2017 (structure data deposition date)
AuthorsNarwal, M. / Jemth, A.S. / Gustafsson, R. / Almlof, I. / Warpman Berglund, U. / Helleday, T. / Stenmark, P.
External linksBiochemistry / PubMed:29281266
MethodsX-ray diffraction
Resolution1.85 - 2.4 Å
Structure data

PDB-5mze:
Crystal structure of mouse MTH1 with 8-oxo-dGTP
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-5mzf:
Crystal structure of dog MTH1 protein
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-5mzg:
Crystal structure of mouse MTH1 in complex with TH588
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-6ehh:
Crystal structure of mouse MTH1 mutant L116M with inhibitor TH588
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-CU:
COPPER (II) ION

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-8DG:
8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-ACT:
ACETATE ION

ChemComp-CL:
Unknown entry

ChemComp-2GE:
N~4~-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine

ChemComp-SCN:
THIOCYANATE ION

ChemComp-NO3:
NITRATE ION

ChemComp-MG:
Unknown entry

Source
  • mus musculus (house mouse)
  • canis lupus familiaris (dog)
KeywordsHYDROLASE / substrate / complex / drug target / Inhibitor / mutant / MTH1 / mouse

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