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TitleDevelopment and characterization of a new inhibitor of heme oxygenase activity for cancer treatment.
Journal, issue, pagesArch. Biochem. Biophys., Vol. 671, Page 130-142, Year 2019
Publish dateSep 12, 2017 (structure data deposition date)
AuthorsMucha, O. / Podkalicka, P. / Mikulski, M. / Barwacz, S. / Andrysiak, K. / Biela, A. / Mieczkowski, M. / Kachamakova-Trojanowska, N. / Ryszawy, D. / Bialas, A. ...Mucha, O. / Podkalicka, P. / Mikulski, M. / Barwacz, S. / Andrysiak, K. / Biela, A. / Mieczkowski, M. / Kachamakova-Trojanowska, N. / Ryszawy, D. / Bialas, A. / Szelazek, B. / Grudnik, P. / Majewska, E. / Michalik, K. / Jakubiec, K. / Bien, M. / Witkowska, N. / Gluza, K. / Ekonomiuk, D. / Sitarz, K. / Galezowski, M. / Brzozka, K. / Dubin, G. / Jozkowicz, A. / Dulak, J. / Loboda, A.
External linksArch. Biochem. Biophys. / PubMed:31276659
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-6eha:
Heme oxygenase 1 in complex with inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-B5B:
1-(3-imidazol-1-ylpropyl)-5-(2-methylpropyl)-4-phenyl-imidazole

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / heme oxygenase

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