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Structure paper

TitleBinding between G Quadruplexes at the Homodimer Interface of the Corn RNA Aptamer Strongly Activates Thioflavin T Fluorescence.
Journal, issue, pagesCell Chem Biol, Vol. 26, Page 1159-, Year 2019
Publish dateJul 27, 2018 (structure data deposition date)
AuthorsSjekloca, L. / Ferre-D'Amare, A.R.
External linksCell Chem Biol / PubMed:31178406
MethodsX-ray diffraction
Resolution2.721 - 3.101 Å
Structure data

PDB-6e80:
Crystal structure of the Corn aptamer in unliganded state
Method: X-RAY DIFFRACTION / Resolution: 2.901 Å

PDB-6e81:
Crystal structure of the Corn aptamer in complex with ThT
Method: X-RAY DIFFRACTION / Resolution: 2.721 Å

PDB-6e82:
Crystal structure of the Corn aptamer mutant A14U in complex with ThT
Method: X-RAY DIFFRACTION / Resolution: 3.101 Å

PDB-6e84:
Crystal structure of the Corn aptamer in complex with TO
Method: X-RAY DIFFRACTION / Resolution: 2.901 Å

Chemicals

ChemComp-IRI:
IRIDIUM HEXAMMINE ION

ChemComp-K:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-ACT:
ACETATE ION

ChemComp-IR:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-TFX:
2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium

ChemComp-J0D:
1-methyl-4-[(Z)-(3-methyl-1,3-benzothiazol-2(3H)-ylidene)methyl]quinolin-1-ium

Source
  • synthetic construct (others)
KeywordsRNA / polyribonucleotide / fluorigenic aptamer / G-quadruplex / apo / thioflavin T / Corn mutant A14U / thiazole orange

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