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TitleStructure of the adenosine-bound human adenosine A receptor-G complex.
Journal, issue, pagesNature, Vol. 558, Issue 7711, Page 559-563, Year 2018
Publish dateJun 20, 2018
AuthorsChristopher J Draper-Joyce / Maryam Khoshouei / David M Thal / Yi-Lynn Liang / Anh T N Nguyen / Sebastian G B Furness / Hariprasad Venugopal / Jo-Anne Baltos / Jürgen M Plitzko / Radostin Danev / Wolfgang Baumeister / Lauren T May / Denise Wootten / Patrick M Sexton / Alisa Glukhova / Arthur Christopoulos /
PubMed AbstractThe class A adenosine A receptor (AR) is a G-protein-coupled receptor that preferentially couples to inhibitory G heterotrimeric G proteins, has been implicated in numerous diseases, yet remains ...The class A adenosine A receptor (AR) is a G-protein-coupled receptor that preferentially couples to inhibitory G heterotrimeric G proteins, has been implicated in numerous diseases, yet remains poorly targeted. Here we report the 3.6 Å structure of the human AR in complex with adenosine and heterotrimeric G protein determined by Volta phase plate cryo-electron microscopy. Compared to inactive AR, there is contraction at the extracellular surface in the orthosteric binding site mediated via movement of transmembrane domains 1 and 2. At the intracellular surface, the G protein engages the AR primarily via amino acids in the C terminus of the Gα α5-helix, concomitant with a 10.5 Å outward movement of the AR transmembrane domain 6. Comparison with the agonist-bound β adrenergic receptor-G-protein complex reveals distinct orientations for each G-protein subtype upon engagement with its receptor. This active AR structure provides molecular insights into receptor and G-protein selectivity.
External linksNature / PubMed:29925945
MethodsEM (single particle)
Resolution3.6 Å
Structure data

7835

6d9h

EMDB-7835, PDB-6d9h:
Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist
Method: EM (single particle) / Resolution: 3.6 Å

Chemicals

ChemComp-ADN:
ADENOSINE

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / membrane protein / active-state G protein-coupled receptor / adenosine A1 receptor

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