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-Structure paper
Title | Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. |
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Journal, issue, pages | Nat Commun, Vol. 9, Page 4508-4508, Year 2018 |
Publish date | Mar 17, 2018 (structure data deposition date) |
Authors | LaRochelle, J.R. / Fodor, M. / Vemulapalli, V. / Mohseni, M. / Wang, P. / Stams, T. / LaMarche, M.J. / Chopra, R. / Acker, M.G. / Blacklow, S.C. |
External links | Nat Commun / PubMed:30375388 |
Methods | X-ray diffraction |
Resolution | 2.62 - 2.75 Å |
Structure data | PDB-6crf: PDB-6crg: |
Chemicals | ChemComp-GOL: ChemComp-HOH: ChemComp-5OD: ChemComp-SO4: |
Source |
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Keywords | HYDROLASE / SHP2 / PTPN11 / PROTEIN TYROSINE PHOSPHATASE / E76K / Gain of Function Mutant / Open Conformation / PHOSPHATASE / HYDROLASE/HYDROLASE INHIBITOR / ALLOSTERIC INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR COMPLEX |