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-Structure paper
Title | Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei |
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Journal, issue, pages | Rsc Med Chem, Vol. 11, Page 885-895, Year 2020 |
Publish date | Mar 5, 2018 (structure data deposition date) |
Authors | Zhang, Z. / Barros-Alvarez, X. / Gillespie, J.R. / Ranade, R.M. / Huang, W. / Shibata, S. / Molasky, N.M.R. / Faghih, O. / Mushtaq, A. / Choy, R.K.M. ...Zhang, Z. / Barros-Alvarez, X. / Gillespie, J.R. / Ranade, R.M. / Huang, W. / Shibata, S. / Molasky, N.M.R. / Faghih, O. / Mushtaq, A. / Choy, R.K.M. / de Hostos, E. / Hol, W.G.J. / Verlinde, C.L.M.J. / Buckner, F.S. / Fan, E. |
External links | Rsc Med Chem / Search PubMed |
Methods | X-ray diffraction |
Resolution | 2.7 - 2.9 Å |
Structure data | PDB-6cml: PDB-6mes: |
Chemicals | ChemComp-MET: ChemComp-96S: ChemComp-GOL: ChemComp-HOH: ChemComp-JFA: |
Source |
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Keywords | ligase/ligase inhibitor / synthetase / ligase / methionine / inhibitor / Ligase-Ligase Inhibitor complex |