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TitleRational Design of a 310-Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp.
Journal, issue, pagesChemistry, Vol. 24, Page 11325-11331, Year 2018
Publish dateFeb 3, 2018 (structure data deposition date)
AuthorsWegener, K.L. / McGrath, A.E. / Dixon, N.E. / Oakley, A.J. / Scanlon, D.B. / Abell, A.D. / Bruning, J.B.
External linksChemistry / PubMed:29917264
MethodsX-ray diffraction / NMR (solution)
Resolution2.75 Å
Structure data

PDB-6cbi:
PCNA in complex with inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

PDB-6cej:
Solution structure of a 14mer fragment of the p21 protein
Method: SOLUTION NMR

PDB-6civ:
Lactam cyclised mimetic of a fragment of p21
Method: SOLUTION NMR

PDB-6cix:
Lactam cyclised mimetic of a fragment of p21
Method: SOLUTION NMR

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / PCNA / sliding clamp / proliferating cell nuclear antigen / PIP-box motif / p21 / BIOSYNTHETIC PROTEIN / constrained / peptidomimetic

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