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TitleStructural Plasticity in the C-Terminal Region of Macrophage Migration Inhibitory Factor-2 Is Associated with an Induced Fit Mechanism for a Selective Inhibitor.
Journal, issue, pagesBiochemistry, Vol. 57, Page 3599-3605, Year 2018
Publish dateJan 16, 2018 (structure data deposition date)
AuthorsPantouris, G. / Bucala, R. / Lolis, E.J.
External linksBiochemistry / PubMed:29847104
MethodsX-ray diffraction
Resolution1.4 Å
Structure data

PDB-6c5f:
Human D-Dopachrome tautomerase (D-DT)/ macrophage migration inhibitory factor 2 (MIF2) complexed with the selective inhibitor 4-CPPC
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

Chemicals

ChemComp-7L9:
4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCYTOKINE / selective inhibitor

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