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Structure paper

TitleA human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.
Journal, issue, pagesNat. Med., Vol. 24, Page 408-416, Year 2018
Publish dateSep 29, 2017 (structure data deposition date)
AuthorsKisalu, N.K. / Idris, A.H. / Weidle, C. / Flores-Garcia, Y. / Flynn, B.J. / Sack, B.K. / Murphy, S. / Schon, A. / Freire, E. / Francica, J.R. ...Kisalu, N.K. / Idris, A.H. / Weidle, C. / Flores-Garcia, Y. / Flynn, B.J. / Sack, B.K. / Murphy, S. / Schon, A. / Freire, E. / Francica, J.R. / Miller, A.B. / Gregory, J. / March, S. / Liao, H.X. / Haynes, B.F. / Wiehe, K. / Trama, A.M. / Saunders, K.O. / Gladden, M.A. / Monroe, A. / Bonsignori, M. / Kanekiyo, M. / Wheatley, A.K. / McDermott, A.B. / Farney, S.K. / Chuang, G.Y. / Zhang, B. / Kc, N. / Chakravarty, S. / Kwong, P.D. / Sinnis, P. / Bhatia, S.N. / Kappe, S.H.I. / Sim, B.K.L. / Hoffman, S.L. / Zavala, F. / Pancera, M. / Seder, R.A.
External linksNat. Med. / PubMed:29554083
MethodsX-ray diffraction
Resolution1.775 - 2.4 Å
Structure data

PDB-6b5l:
Structure of PfCSP peptide 20 with human protective antibody CIS43
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-6b5m:
Structure of PfCSP peptide 21 with human protective antibody CIS43
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

PDB-6b5n:
Structure of PfCSP peptide 25 with human protective antibody CIS43
Method: X-RAY DIFFRACTION / Resolution: 1.98 Å

PDB-6b5o:
Structure of PfCSP peptide 29 with human protective antibody CIS43
Method: X-RAY DIFFRACTION / Resolution: 2.194 Å

PDB-6b5p:
Structure of PfCSP peptide 20 with human antibody CIS42
Method: X-RAY DIFFRACTION / Resolution: 2.297 Å

PDB-6b5r:
Structure of PfCSP peptide 21 with human antibody CIS42
Method: X-RAY DIFFRACTION / Resolution: 1.775 Å

PDB-6b5s:
Structure of PfCSP peptide 25 with human antibody CIS42
Method: X-RAY DIFFRACTION / Resolution: 1.983 Å

PDB-6b5t:
Structure of PfCSP peptide 29 with human antibody CIS42
Method: X-RAY DIFFRACTION / Resolution: 2.222 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-NH4:
AMMONIUM ION

ChemComp-NA:
Unknown entry

Source
  • homo sapiens (human)
  • plasmodium falciparum (malaria parasite P. falciparum)
KeywordsIMMUNE SYSTEM / Malaria / pfCSP / vaccine / antibodies

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