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TitleThe crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate.
Journal, issue, pagesActa Crystallogr F Struct Biol Commun, Vol. 74, Page 245-254, Year 2018
Publish dateSep 6, 2017 (structure data deposition date)
AuthorsBarros-Alvarez, X. / Turley, S. / Ranade, R.M. / Gillespie, J.R. / Duster, N.A. / Verlinde, C.L.M.J. / Fan, E. / Buckner, F.S. / Hol, W.G.J.
External linksActa Crystallogr F Struct Biol Commun / PubMed:29633973
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-6ax8:
Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with methionyl-adenylate
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-ME8:
[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]

ChemComp-HOH:
WATER

Source
  • mycobacterium tuberculosis (strain atcc 25618 / h37rv) (bacteria)
KeywordsLIGASE / synthetase / Ligase-aminoacyl adenylate complex

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