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TitleStructural insights into the mechanism of action of a biparatopic anti-HER2 antibody.
Journal, issue, pagesJ. Biol. Chem., Vol. 293, Page 8439-8448, Year 2018
Publish dateAug 29, 2017 (structure data deposition date)
AuthorsOganesyan, V. / Peng, L. / Bee, J.S. / Li, J. / Perry, S.R. / Comer, F. / Xu, L. / Cook, K. / Senthil, K. / Clarke, L. ...Oganesyan, V. / Peng, L. / Bee, J.S. / Li, J. / Perry, S.R. / Comer, F. / Xu, L. / Cook, K. / Senthil, K. / Clarke, L. / Rosenthal, K. / Gao, C. / Damschroder, M. / Wu, H. / Dall'Acqua, W.
External linksJ. Biol. Chem. / PubMed:29669810
MethodsX-ray diffraction
Resolution3.77 Å
Structure data

PDB-6att:
39S Fab bound to HER2 ecd
Method: X-RAY DIFFRACTION / Resolution: 3.77 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Antibody / fragment antigen binding / HER2 / receptor

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