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TitleMolecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis.
Journal, issue, pagesAnn. Rheum. Dis., Vol. 76, Page 1915-1923, Year 2017
Publish dateAug 29, 2017 (structure data deposition date)
AuthorsScally, S.W. / Law, S.C. / Ting, Y.T. / Heemst, J.V. / Sokolove, J. / Deutsch, A.J. / Bridie Clemens, E. / Moustakas, A.K. / Papadopoulos, G.K. / Woude, D.V. ...Scally, S.W. / Law, S.C. / Ting, Y.T. / Heemst, J.V. / Sokolove, J. / Deutsch, A.J. / Bridie Clemens, E. / Moustakas, A.K. / Papadopoulos, G.K. / Woude, D.V. / Smolik, I. / Hitchon, C.A. / Robinson, D.B. / Ferucci, E.D. / Bernstein, C.N. / Meng, X. / Anaparti, V. / Huizinga, T. / Kedzierska, K. / Reid, H.H. / Raychaudhuri, S. / Toes, R.E. / Rossjohn, J. / El-Gabalawy, H. / Thomas, R.
External linksAnn. Rheum. Dis. / PubMed:28801345
MethodsX-ray diffraction
Resolution1.9 - 2.7 Å
Structure data

PDB-6atf:
HLA-DRB1*1402 in complex with Vimentin59-71
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-6ati:
HLA-DRB1*1402 in complex with Vimentin-64Cit59-71
Method: X-RAY DIFFRACTION / Resolution: 1.98 Å

PDB-6atz:
HLA-DRB1*1402 in complex with citrullinated fibrinogen peptide
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-HOH:
WATER

ChemComp-B3P:
2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / HLA Class II / HLA / MHC / citrulline / Rheumatoid Arthritis

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