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-Structure paper
Title | Optimization of Chromeno[2,3- c]pyrrol-9(2 H)-ones as Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 8468-8473, Year 2018 |
Publish date | May 29, 2018 (structure data deposition date) |
Authors | Wu, D. / Huang, Y. / Chen, Y. / Huang, Y.Y. / Geng, H. / Zhang, T. / Zhang, C. / Li, Z. / Guo, L. / Chen, J. / Luo, H.B. |
External links | J. Med. Chem. / PubMed:30148362 |
Methods | X-ray diffraction |
Resolution | 2.6 - 2.8 Å |
Structure data | PDB-5zz2: PDB-6acb: |
Chemicals | ChemComp-ZN: ChemComp-MG: ChemComp-SO4: ChemComp-9M0: ChemComp-HOH: ChemComp-9T9: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / PDE5 inhibitor LW1634 / HYDROLASE-HYDROLASE INHIBITOR complex / PDE5 in complex with inhibitor LW1805 |