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-Structure paper
Title | Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1 H-pyrazol-4-yl)-1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- b]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor. |
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Journal, issue, pages | J. Med. Chem., Vol. 62, Page 531-551, Year 2019 |
Publish date | Apr 23, 2018 (structure data deposition date) |
Authors | Uno, T. / Kawai, Y. / Yamashita, S. / Oshiumi, H. / Yoshimura, C. / Mizutani, T. / Suzuki, T. / Chong, K.T. / Shigeno, K. / Ohkubo, M. ...Uno, T. / Kawai, Y. / Yamashita, S. / Oshiumi, H. / Yoshimura, C. / Mizutani, T. / Suzuki, T. / Chong, K.T. / Shigeno, K. / Ohkubo, M. / Kodama, Y. / Muraoka, H. / Funabashi, K. / Takahashi, K. / Ohkubo, S. / Kitade, M. |
External links | J. Med. Chem. / PubMed:30525599 |
Methods | X-ray diffraction |
Resolution | 2.5 Å |
Structure data | PDB-5zr3: |
Chemicals | ChemComp-9J0: ChemComp-HOH: |
Source |
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Keywords | CHAPERONE / Inhibitor / Complex |