- PDB-5zr3: Crystal structure of Hsp90-alpha N-terminal domain in complex wit... -
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Basic information
Entry
Database: PDB / ID: 5zr3
Title
Crystal structure of Hsp90-alpha N-terminal domain in complex with 4-(3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3-methylbenzamide
Components
Heat shock protein HSP 90-alphaHeat shock response
Keywords
CHAPERONE / Inhibitor / Complex
Function / homology
Function and homology information
Scavenging by Class F Receptors / positive regulation of protein polymerization / vRNP Assembly / telomerase holoenzyme complex assembly / protein insertion into mitochondrial outer membrane / Uptake and function of diphtheria toxin / chaperone-mediated autophagy / central nervous system neuron axonogenesis / mitochondrial transport / Resistance of ERBB2 KD mutants to neratinib ...Scavenging by Class F Receptors / positive regulation of protein polymerization / vRNP Assembly / telomerase holoenzyme complex assembly / protein insertion into mitochondrial outer membrane / Uptake and function of diphtheria toxin / chaperone-mediated autophagy / central nervous system neuron axonogenesis / mitochondrial transport / Resistance of ERBB2 KD mutants to neratinib / Drug-mediated inhibition of ERBB2 signaling / Resistance of ERBB2 KD mutants to sapitinib / Resistance of ERBB2 KD mutants to tesevatinib / Resistance of ERBB2 KD mutants to trastuzumab / Resistance of ERBB2 KD mutants to afatinib / Resistance of ERBB2 KD mutants to AEE788 / Resistance of ERBB2 KD mutants to lapatinib / Drug resistance in ERBB2 TMD/JMD mutants / Resistance of ERBB2 KD mutants to osimertinib / positive regulation of protein catabolic process => GO:0045732 / TPR domain binding / PIWI-interacting RNA (piRNA) biogenesis / non-chaperonin molecular chaperone ATPase / dendritic growth cone / regulation of protein ubiquitination / protein unfolding / chaperone-mediated protein complex assembly / axon extension / Sema3A PAK dependent Axon repulsion / telomere maintenance via telomerase / positive regulation of tau-protein kinase activity / RHOBTB2 GTPase cycle / HSF1-dependent transactivation / response to unfolded protein / HSF1 activation / DNA polymerase binding / regulation of protein-containing complex assembly / Attenuation phase / axonal growth cone / eNOS activation / establishment of cell polarity / positive regulation of defense response to virus by host / Loss of proteins required for interphase microtubule organization from the centrosome / Loss of Nlp from mitotic centrosomes / Recruitment of mitotic centrosome proteins and complexes / protein tyrosine kinase binding / Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation / response to cold / Recruitment of NuMA to mitotic centrosomes / Signaling by ERBB2 / Anchoring of the basal body to the plasma membrane / activation of innate immune response / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / protein folding chaperone / endocytic vesicle lumen / positive regulation of telomerase activity / positive regulation of interferon-beta production / lysosomal lumen / AURKA Activation by TPX2 / nitric-oxide synthase regulator activity / Constitutive Signaling by Overexpressed ERBB2 / ESR-mediated signaling / VEGFR2 mediated vascular permeability / Signaling by ERBB2 TMD/JMD mutants / tau protein binding / GTPase binding / DDX58/IFIH1-mediated induction of interferon-alpha/beta / Constitutive Signaling by EGFRvIII / Signaling by ERBB2 ECD mutants / Regulation of necroptotic cell death / Signaling by ERBB2 KD Mutants / Downregulation of ERBB2 signaling / Aggrephagy / cellular response to virus / VEGFA-VEGFR2 Pathway / Regulation of actin dynamics for phagocytic cup formation / Chaperone Mediated Autophagy / histone deacetylase binding / melanosome / regulation of protein localization / The role of GTSE1 in G2/M progression after G2 checkpoint / Regulation of PLK1 Activity at G2/M Transition / unfolded protein binding / protein folding / positive regulation of nitric oxide biosynthetic process / Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants / cellular response to heat / disordered domain specific binding / scaffold protein binding / myelin sheath / MHC class II protein complex binding / Potential therapeutics for SARS / Extra-nuclear estrogen signaling / protein refolding / positive regulation of peptidyl-serine phosphorylation / response to heat / secretory granule lumen / Estrogen-dependent gene expression / Interleukin-4 and Interleukin-13 signaling / protein stabilization Similarity search - Function
Heat shock hsp90 proteins family signature. / Heat shock protein Hsp90, conserved site / Heat shock protein Hsp90, N-terminal / Heat shock protein Hsp90 family / HSP90, C-terminal domain / Hsp90 protein / Histidine kinase-like ATPase, C-terminal domain / Heat Shock Protein 90 / Histidine kinase-like ATPases / Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase ...Heat shock hsp90 proteins family signature. / Heat shock protein Hsp90, conserved site / Heat shock protein Hsp90, N-terminal / Heat shock protein Hsp90 family / HSP90, C-terminal domain / Hsp90 protein / Histidine kinase-like ATPase, C-terminal domain / Heat Shock Protein 90 / Histidine kinase-like ATPases / Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase / Histidine kinase/HSP90-like ATPase / Histidine kinase/HSP90-like ATPase superfamily / Ribosomal protein S5 domain 2-type fold / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homology
Resolution: 2.5→102.33 Å / Cor.coef. Fo:Fc: 0.943 / Cor.coef. Fo:Fc free: 0.909 / SU B: 11.245 / SU ML: 0.241 / SU R Cruickshank DPI: 0.5322 / Cross valid method: THROUGHOUT / σ(F): 0 / ESU R: 0.532 / ESU R Free: 0.293 Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : REFINED INDIVIDUALLY
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.2535
1956
5.5 %
RANDOM
Rwork
0.2023
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obs
0.2053
33829
97.07 %
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Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å
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