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TitleOptimization of Novel Quinazolines as Potent Aurora Kinase Inhibitors for Triple-Negative Breast Cancer Treatment.
Journal, issue, pagesJ. Med. Chem., Vol. 68, Page 18197-18215, Year 2025
Publish dateFeb 7, 2018 (structure data deposition date)
AuthorsLong, L. / Zhang, B. / Peng, W. / Pan, Y. / Zhai, H. / Cheng, B. / Tu, Z. / Long, Z. / Zhou, H. / Liu, Q. / Lu, G.
External linksJ. Med. Chem. / PubMed:40852972
MethodsX-ray diffraction
Resolution2.85 Å
Structure data

PDB-5zan:
Crystal Structure of Aurora-A in complex with a new Quinazoline inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

Chemicals

ChemComp-9A6:
7-(4-methylpiperazin-1-yl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(E)-2-phenylethenyl]quinazolin-4-amine

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/INHIBITOR / Drug Design / TRANSFERASE / TRANSFERASE-INHIBITOR complex

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