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TitleStructure-Based Design of a Eukaryote-Selective Antiprotozoal Fluorinated Aminoglycoside.
Journal, issue, pagesChemMedChem, Vol. 13, Page 1541-1548, Year 2018
Publish dateDec 26, 2017 (structure data deposition date)
AuthorsKanazawa, H. / Saavedra, O.M. / Maianti, J.P. / Young, S.A. / Izquierdo, L. / Smith, T.K. / Hanessian, S. / Kondo, J.
External linksChemMedChem / PubMed:29766661
MethodsX-ray diffraction
Resolution1.903 - 2.4 Å
Structure data

PDB-5z1h:
Crystal structure of the bacterial ribosomal decoding site in complex with 6'-fluoro sisomicin
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-5z1i:
Crystal structure of the protozoal cytoplasmic ribosomal decoding site in complex with 6'-fluoro sisomicin
Method: X-RAY DIFFRACTION / Resolution: 1.903 Å

Chemicals

ChemComp-FSJ:
(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(fluoromethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
KeywordsRNA / rRNA / aminoglycoside

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