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Structure paper

TitleA multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA.
Journal, issue, pagesNat Commun, Vol. 9, Page 2669-2669, Year 2018
Publish dateJun 8, 2017 (structure data deposition date)
AuthorsBangaru, S. / Zhang, H. / Gilchuk, I.M. / Voss, T.G. / Irving, R.P. / Gilchuk, P. / Matta, P. / Zhu, X. / Lang, S. / Nieusma, T. ...Bangaru, S. / Zhang, H. / Gilchuk, I.M. / Voss, T.G. / Irving, R.P. / Gilchuk, P. / Matta, P. / Zhu, X. / Lang, S. / Nieusma, T. / Richt, J.A. / Albrecht, R.A. / Vanderven, H.A. / Bombardi, R. / Kent, S.J. / Ward, A.B. / Wilson, I.A. / Crowe, J.E.
External linksNat Commun / PubMed:29991715
MethodsX-ray diffraction
Resolution2.6 - 3.569 Å
Structure data

PDB-5w42:
Crystal structure of human monoclonal antibody H3v-47 in complex with influenza virus hemagglutinin from A/Minnesota/11/2010 (H3N2)
Method: X-RAY DIFFRACTION / Resolution: 3.569 Å

PDB-5xrq:
Crystal structure of human monoclonal antibody H3v-47
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-5xrs:
Crystal structure of A/Minnesota/11/2010 (H3N2) influenza virus hemagglutinin in complex with LSTc
Method: X-RAY DIFFRACTION / Resolution: 2.907 Å

PDB-5xrt:
Crystal structure of A/Minnesota/11/2010 (H3N2) influenza virus hemagglutinin
Method: X-RAY DIFFRACTION / Resolution: 3.15 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CAC:
CACODYLATE ION

Source
  • influenza a virus (a/swine/minnesota/a01134337/2010(h3n2))
  • influenza a virus
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Hemagglutinin / antibody / complex / VIRAL PROTEIN / Fab / heavy chain / light chain / influenza virus / human receptor analog / LSTc / receptor binding / antigen protein

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