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TitleInteractions between sirtuins and fluorogenic small-molecule substrates offer insights into inhibitor design
Journal, issue, pagesRsc Adv, Vol. 7, Page 36214-36222, Year 2017
Publish dateApr 24, 2017 (structure data deposition date)
AuthorsWang, H.L. / Liu, S. / Yu, Z.J. / Wu, C. / Cheng, L. / Wang, Y. / Chen, K. / Zhou, S. / Chen, Q. / Yu, Y. / Li, G.B.
External linksRsc Adv / Search PubMed
MethodsX-ray diffraction
Resolution2.19 Å
Structure data

PDB-5xhs:
Crystal structure of SIRT5 complexed with a fluorogenic small-molecule substrate SuBKA
Method: X-RAY DIFFRACTION / Resolution: 2.19 Å

Chemicals

ChemComp-PHQ:
benzyl chlorocarbonate

ChemComp-SLL:
(2S)-2-azanyl-6-[(4-hydroxy-4-oxo-butanoyl)amino]hexanoic acid

ChemComp-MCM:
7-AMINO-4-METHYL-CHROMEN-2-ONE

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Sirtuin / Fluorogenic Small Molecule Substrates

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