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Structure paper

TitleA novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1.
Journal, issue, pagesActa Crystallogr F Struct Biol Commun, Vol. 74, Page 156-160, Year 2018
Publish dateDec 24, 2016 (structure data deposition date)
AuthorsMatsui, Y. / Yasumatsu, I. / Yoshida, K.I. / Iimura, S. / Ikeno, Y. / Nawano, T. / Fukano, H. / Ubukata, O. / Hanzawa, H. / Tanzawa, F. / Isoyama, T.
External linksActa Crystallogr F Struct Biol Commun / PubMed:29497019
MethodsX-ray diffraction
Resolution3 Å
Structure data

PDB-5wvd:
Structure of Mnk1 in complex with DS12881479
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-7UX:
1-methyl-N-(5-phenyl-1,3-thiazol-2-yl)piperidine-4-carboxamide

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / kinase / kinase inhibitor / inactive conformation

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