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Structure paper

TitleStructures of beta-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
Journal, issue, pagesNature, Vol. 553, Page 501-505, Year 2018
Publish dateMar 27, 2017 (structure data deposition date)
AuthorsLee, S. / Choi, J. / Mohanty, J. / Sousa, L.P. / Tome, F. / Pardon, E. / Steyaert, J. / Lemmon, M.A. / Lax, I. / Schlessinger, J.
External linksNature / PubMed:29342135
MethodsX-ray diffraction
Resolution1.7 - 2.606 Å
Structure data

PDB-5vak:
Crystal Structure of Beta-Klotho, Domain 1
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-5van:
Crystal Structure of Beta-Klotho
Method: X-RAY DIFFRACTION / Resolution: 2.202 Å

PDB-5vaq:
Crystal Structure of Beta-Klotho in Complex with FGF21CT
Method: X-RAY DIFFRACTION / Resolution: 2.606 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-MAN:
alpha-D-mannopyranose

ChemComp-BGC:
beta-D-glucopyranose

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsSIGNALING PROTEIN / (beta/alpha)8 / (beta/alpha)8 Receptor for Endocrine FGF / (beta/alpha) 8 Receptor for Endocrine FGF

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