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Structure paper

TitleLa-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs.
Journal, issue, pagesElife, Vol. 6, Year 2017
Publish dateMar 10, 2017 (structure data deposition date)
AuthorsLahr, R.M. / Fonseca, B.D. / Ciotti, G.E. / Al-Ashtal, H.A. / Jia, J.J. / Niklaus, M.R. / Blagden, S.P. / Alain, T. / Berman, A.J.
External linksElife / PubMed:28379136
MethodsX-ray diffraction
Resolution1.692 - 2.59 Å
Structure data

PDB-5v4r:
Crystal structure of LARP1-unique domain DM15 bound to m7GTP
Method: X-RAY DIFFRACTION / Resolution: 1.77 Å

PDB-5v7c:
Crystal structure of LARP1-unique domain DM15 bound 5'TOP RNA sequence
Method: X-RAY DIFFRACTION / Resolution: 2.59 Å

PDB-5v87:
Crystal structure of LARP1-unique domain DM15 bound to m7GpppC
Method: X-RAY DIFFRACTION / Resolution: 1.692 Å

Chemicals

ChemComp-MGT:
7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE

ChemComp-HOH:
WATER

ChemComp-91P:
[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-9-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [[(2~{R},3~{S},4~{R},5~{R})-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate

Source
  • homo sapiens (human)
KeywordsRNA BINDING PROTEIN / Cap-binding / RNA-binding / DM15 / 5'TOP

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