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TitleA novel CLK inhibitor exhibits anti-tumor efficacies via modulating pre-mRNA splicing and targeting a MYC-dependent vulnerability
Journal, issue, pagesEmbo Mol Med, Year 2018
Publish dateJan 31, 2017 (structure data deposition date)
AuthorsIwai, K. / Yaguchi, M. / Klein, M.G.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.92 Å
Structure data

PDB-5unp:
Structure of CDC2-Like Kinase 2 (CLK2) in Complex with Compound T-025 [N2-methyl-N4-(pyrimidin-2-ylmethyl)-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine]
Method: X-RAY DIFFRACTION / Resolution: 2.92 Å

Chemicals

ChemComp-8FY:
N~2~-methyl-N~4~-[(pyrimidin-2-yl)methyl]-5-(quinolin-6-yl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE INHIBITOR / Protein Kinase / Dual Specificity Protein Kinase / Inhibitor / Transferase / complex / TRANSFERASE-TRANSFERASE INHIBITOR complex

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