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Structure paper

Title3.3 angstrom structure of Niemann-Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport.
Journal, issue, pagesProc. Natl. Acad. Sci. U.S.A., Vol. 114, Page 9116-9121, Year 2017
Publish dateDec 11, 2016 (structure data deposition date)
AuthorsLi, X. / Lu, F. / Trinh, M.N. / Schmiege, P. / Seemann, J. / Wang, J. / Blobel, G.
External linksProc. Natl. Acad. Sci. U.S.A. / PubMed:28784760
MethodsX-ray diffraction
Resolution3.335 - 3.348 Å
Structure data

PDB-5u73:
Crystal structure of human Niemann-Pick C1 protein
Method: X-RAY DIFFRACTION / Resolution: 3.348 Å

PDB-5u74:
Structure of human Niemann-Pick C1 protein
Method: X-RAY DIFFRACTION / Resolution: 3.335 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / NPC1

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