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Structure paper

TitleStructural Basis of Alcohol Inhibition of the Pentameric Ligand-Gated Ion Channel ELIC.
Journal, issue, pagesStructure, Vol. 25, Page 180-187, Year 2017
Publish dateAug 10, 2016 (structure data deposition date)
AuthorsChen, Q. / Wells, M.M. / Tillman, T.S. / Kinde, M.N. / Cohen, A. / Xu, Y. / Tang, P.
External linksStructure / PubMed:27916519
MethodsX-ray diffraction
Resolution3.1 - 3.4 Å
Structure data

PDB-5sxu:
X-ray structure of 2-bromoethanol bound to a pentameric ligand gated ion channel (ELIC) in a desensitized state
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-5sxv:
X-ray structure of 2-bromoethanol bound to a pentameric ligand gated ion channel (ELIC) in a resting state
Method: X-RAY DIFFRACTION / Resolution: 3.4 Å

Chemicals

ChemComp-BRJ:
2-BROMOETHANOL

ChemComp-3CN:
3-AMINOPROPANE

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • dickeya dadantii (strain 3937) (bacteria)
  • dickeya chrysanthemi (bacteria)
KeywordsPROTEIN TRANSPORT / ELIC / anesthetic / ethanol / desensitized state / TRANSPORT PROTEIN / resting state

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