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Structure paper

TitleMechanism of RNA polymerase II stalling by DNA alkylation.
Journal, issue, pagesProc. Natl. Acad. Sci. U.S.A., Vol. 114, Page 12172-12177, Year 2017
Publish dateAug 19, 2017 (structure data deposition date)
AuthorsMalvezzi, S. / Farnung, L. / Aloisi, C.M.N. / Angelov, T. / Cramer, P. / Sturla, S.J.
External linksProc. Natl. Acad. Sci. U.S.A. / PubMed:29087308
MethodsX-ray diffraction
Resolution3.2 Å
Structure data

PDB-5ot2:
RNA polymerase II elongation complex in the presence of 3d-Napht-A
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-AHW:
2-ethyl-7-methoxy-naphthalene

Source
  • saccharomyces cerevisiae (strain atcc 204508 / s288c) (yeast)
  • synthetic construct (others)
KeywordsTRANSCRIPTION / Inhibitor / Complex / Polymerase

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