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-Structure paper
Title | Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation. |
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Journal, issue, pages | J. Med. Chem., Vol. 60, Page 10257-10267, Year 2017 |
Publish date | May 29, 2017 (structure data deposition date) |
![]() | Taban, I.M. / Elshihawy, H.E.A.E. / Torun, B. / Zucchini, B. / Williamson, C.J. / Altuwairigi, D. / Ngu, A.S.T. / McLean, K.J. / Levy, C.W. / Sood, S. ...Taban, I.M. / Elshihawy, H.E.A.E. / Torun, B. / Zucchini, B. / Williamson, C.J. / Altuwairigi, D. / Ngu, A.S.T. / McLean, K.J. / Levy, C.W. / Sood, S. / Marino, L.B. / Munro, A.W. / de Carvalho, L.P.S. / Simons, C. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.345 - 1.64 Å |
Structure data | ![]() PDB-5o4k: ![]() PDB-5o4l: ![]() PDB-5op9: ![]() PDB-5opa: |
Chemicals | ![]() ChemComp-SO4: ![]() ChemComp-HEM: ![]() ChemComp-9KE: ![]() ChemComp-HOH: ![]() ChemComp-9KB: ![]() ChemComp-BZ6: ![]() ChemComp-A2W: ![]() ChemComp-PEG: |
Source |
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![]() | OXIDOREDUCTASE / Cytochrome P450 Redox Inhibitor / Cytochrome P450 Inhibitor complex |