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Structure paper

TitleThe Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth.
Journal, issue, pagesStructure, Vol. 26, Page 416-425.e4, Year 2018
Publish dateAug 3, 2017 (structure data deposition date)
AuthorsPellegrino, S. / Meyer, M. / Zorbas, C. / Bouchta, S.A. / Saraf, K. / Pelly, S.C. / Yusupova, G. / Evidente, A. / Mathieu, V. / Kornienko, A. ...Pellegrino, S. / Meyer, M. / Zorbas, C. / Bouchta, S.A. / Saraf, K. / Pelly, S.C. / Yusupova, G. / Evidente, A. / Mathieu, V. / Kornienko, A. / Lafontaine, D.L.J. / Yusupov, M.
External linksStructure / PubMed:29429877
MethodsX-ray diffraction
Resolution3.10000240787 Å
Structure data

PDB-5on6:
Crystal structure of haemanthamine bound to the 80S ribosome
Method: X-RAY DIFFRACTION / Resolution: 3.10000240787 Å

Chemicals

ChemComp-OHX:
osmium (III) hexammine

ChemComp-MG:
Unknown entry

ChemComp-HN8:
Haemanthamine / alkaloid*YM

ChemComp-GOL:
GLYCEROL

ChemComp-ZN:
Unknown entry

Source
  • saccharomyces cerevisiae (strain atcc 204508 / s288c) (yeast)
KeywordsRIBOSOME / Inhibitor / Cancer

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