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-Structure paper
Title | Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms. |
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Journal, issue, pages | Nat Commun, Vol. 9, Page 651-651, Year 2018 |
Publish date | Jul 10, 2017 (structure data deposition date) |
Authors | Douse, C.H. / Bloor, S. / Liu, Y. / Shamin, M. / Tchasovnikarova, I.A. / Timms, R.T. / Lehner, P.J. / Modis, Y. |
External links | Nat Commun / PubMed:29440755 |
Methods | X-ray diffraction |
Resolution | 1.807 - 2.57 Å |
Structure data | PDB-5of9: PDB-5ofa: PDB-5ofb: |
Chemicals | ChemComp-ZN: ChemComp-ANP: ChemComp-MG: ChemComp-HOH: ChemComp-ATP: |
Source |
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Keywords | NUCLEAR PROTEIN / GHKL ATPase / chromatin remodeler / epigenetic silencing / transcriptional repressor / coiled-coil / CW domain / DNA binding protein / Charcot-Marie-Tooth disease / spinal muscular atrophy |