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TitleHeparan sulfate proteoglycans present PCSK9 to the LDL receptor.
Journal, issue, pagesNat Commun, Vol. 8, Page 503-503, Year 2017
Publish dateJun 30, 2017 (structure data deposition date)
AuthorsGustafsen, C. / Olsen, D. / Vilstrup, J. / Lund, S. / Reinhardt, A. / Wellner, N. / Larsen, T. / Andersen, C.B.F. / Weyer, K. / Li, J.P. ...Gustafsen, C. / Olsen, D. / Vilstrup, J. / Lund, S. / Reinhardt, A. / Wellner, N. / Larsen, T. / Andersen, C.B.F. / Weyer, K. / Li, J.P. / Seeberger, P.H. / Thirup, S. / Madsen, P. / Glerup, S.
External linksNat Commun / PubMed:28894089
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-5oca:
PCSK9:Fab Complex with Dextran Sulfate
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / PROTEIN FAB COMPLEX / AUTOCATALYTIC CLEAVAGE / CHOLESTEROL METABOLISM / DISEASE MUTATION / DISULFIDE BOND / GLYCOPROTEIN / LIPID METABOLISM / PHOSPHOPROTEIN / PROTEASE / SECRETED / SERINE PROTEASE / STEROID METABOLISM / ZYMOGEN / HYDROLASE-IMMUNE SYSTEM COMPLEX

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