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TitleCrystal structure of the first bromodomain of human BRD4 in complex with a tetrahydroquinoline analogue
Journal, issue, pagesTo Be Published
Publish dateFeb 7, 2017 (structure data deposition date)
AuthorsTallant, C. / Slavish, P.J. / Siejka, P. / Bharatham, N. / Shadrick, W.R. / Chai, S. / Young, B.M. / Boyd, V.A. / Heroven, C. / Wiggers, H.J. ...Tallant, C. / Slavish, P.J. / Siejka, P. / Bharatham, N. / Shadrick, W.R. / Chai, S. / Young, B.M. / Boyd, V.A. / Heroven, C. / Wiggers, H.J. / Picaud, S. / Fedorov, O. / Krojer, T. / Chen, T. / Lee, R.E. / Guy, R.K. / Shelat, A.A. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Knapp, S. / Structural Genomics Consortium (SGC)
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.54 Å
Structure data

PDB-5n2m:
Crystal structure of the first bromodomain of human BRD4 in complex with a tetrahydroquinoline analogue
Method: X-RAY DIFFRACTION / Resolution: 1.54 Å

Chemicals

ChemComp-8J2:
propan-2-yl ~{N}-[(2~{S},4~{R})-6-(3-acetamidophenyl)-1-ethanoyl-2-methyl-3,4-dihydro-2~{H}-quinolin-4-yl]carbamate

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / Structural Genomics / Structural Genomics Consortium / SGC

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