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Structure paper

TitleInhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A.
Journal, issue, pagesCell Chem Biol, Vol. 24, Page 605-613.e5, Year 2017
Publish dateNov 15, 2016 (structure data deposition date)
AuthorsMcClary, B. / Zinshteyn, B. / Meyer, M. / Jouanneau, M. / Pellegrino, S. / Yusupova, G. / Schuller, A. / Reyes, J.C.P. / Lu, J. / Guo, Z. ...McClary, B. / Zinshteyn, B. / Meyer, M. / Jouanneau, M. / Pellegrino, S. / Yusupova, G. / Schuller, A. / Reyes, J.C.P. / Lu, J. / Guo, Z. / Ayinde, S. / Luo, C. / Dang, Y. / Romo, D. / Yusupov, M. / Green, R. / Liu, J.O.
External linksCell Chem Biol / PubMed:28457705
MethodsX-ray diffraction
Resolution3.5 Å
Structure data

PDB-5mei:
Crystal structure of Agelastatin A bound to the 80S ribosome
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

Chemicals

ChemComp-OHX:
osmium (III) hexammine

ChemComp-MG:
Unknown entry

ChemComp-7MB:
Agelastatin A

ChemComp-ZN:
Unknown entry

Source
  • saccharomyces cerevisiae (strain atcc 204508 / s288c) (yeast)
KeywordsRIBOSOME / 80S ribosome / protein synthesis inhibitor

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