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Title | Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity. |
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Journal, issue, pages | J. Med. Chem., Vol. 60, Page 2344-2360, Year 2017 |
Publish date | Nov 4, 2016 (structure data deposition date) |
Authors | Moniot, S. / Forgione, M. / Lucidi, A. / Hailu, G.S. / Nebbioso, A. / Carafa, V. / Baratta, F. / Altucci, L. / Giacche, N. / Passeri, D. ...Moniot, S. / Forgione, M. / Lucidi, A. / Hailu, G.S. / Nebbioso, A. / Carafa, V. / Baratta, F. / Altucci, L. / Giacche, N. / Passeri, D. / Pellicciari, R. / Mai, A. / Steegborn, C. / Rotili, D. |
External links | J. Med. Chem. / PubMed:28240897 |
Methods | X-ray diffraction |
Resolution | 1.89 Å |
Structure data | PDB-5mar: |
Chemicals | ChemComp-ZN: ChemComp-AR6: ChemComp-7KE: ChemComp-EDO: ChemComp-DMS: ChemComp-GOL: ChemComp-ACT: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / Sirtuin / NAD-dependent Protein deacylase / Inhibitor Complex |