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Structure paper

TitleNUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.
Journal, issue, pagesCancer Res., Vol. 76, Page 5501-5511, Year 2016
Publish dateAug 12, 2016 (structure data deposition date)
AuthorsValerie, N.C. / Hagenkort, A. / Page, B.D. / Masuyer, G. / Rehling, D. / Carter, M. / Bevc, L. / Herr, P. / Homan, E. / Sheppard, N.G. ...Valerie, N.C. / Hagenkort, A. / Page, B.D. / Masuyer, G. / Rehling, D. / Carter, M. / Bevc, L. / Herr, P. / Homan, E. / Sheppard, N.G. / Stenmark, P. / Jemth, A.S. / Helleday, T.
External linksCancer Res. / PubMed:27530327
MethodsX-ray diffraction
Resolution1.7 Å
Structure data

PDB-5lpg:
Structure of NUDT15 in complex with 6-thio-GMP
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-71V:
[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-sulfanyl-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / MTH2 / DNA repair enzyme / Cancer

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