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Structure paper

TitleTools for the rational design of bivalent microtubule-targeting drugs.
Journal, issue, pagesBiochem. Biophys. Res. Commun., Vol. 479, Page 48-53, Year 2016
Publish dateAug 11, 2016 (structure data deposition date)
AuthorsMarangon, J. / Christodoulou, M.S. / Casagrande, F.V. / Tiana, G. / Dalla Via, L. / Aliverti, A. / Passarella, D. / Cappelletti, G. / Ricagno, S.
External linksBiochem. Biophys. Res. Commun. / PubMed:27613098
MethodsX-ray diffraction
Resolution2.9 Å
Structure data

PDB-5lp6:
Crystal structure of Tubulin-Stathmin-TTL-Thiocolchicine Complex
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-71P:
~{N}-[(7~{R})-1,2,3-trimethoxy-10-methylsulfanyl-9-oxidanylidene-6,7-dihydro-5~{H}-benzo[a]heptalen-7-yl]ethanamide

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
  • gallus gallus (chicken)
  • bos taurus (domestic cattle)
KeywordsSTRUCTURAL PROTEIN / Microtubules / thiocolchicine / tubulin / tubulin-tyrosine ligase

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