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TitleAtomic structure of a rhinovirus C, a virus species linked to severe childhood asthma.
Journal, issue, pagesProc Natl Acad Sci U S A, Vol. 113, Issue 32, Page 8997-9002, Year 2016
Publish dateAug 9, 2016
AuthorsYue Liu / Marchel G Hill / Thomas Klose / Zhenguo Chen / Kelly Watters / Yury A Bochkov / Wen Jiang / Ann C Palmenberg / Michael G Rossmann /
PubMed AbstractIsolates of rhinovirus C (RV-C), a recently identified Enterovirus (EV) species, are the causative agents of severe respiratory infections among children and are linked to childhood asthma ...Isolates of rhinovirus C (RV-C), a recently identified Enterovirus (EV) species, are the causative agents of severe respiratory infections among children and are linked to childhood asthma exacerbations. The RV-C have been refractory to structure determination because they are difficult to propagate in vitro. Here, we report the cryo-EM atomic structures of the full virion and native empty particle (NEP) of RV-C15a. The virus has 60 "fingers" on the virus outer surface that probably function as dominant immunogens. Because the NEPs also display these fingers, they may have utility as vaccine candidates. A sequence-conserved surface depression adjacent to each finger forms a likely binding site for the sialic acid on its receptor. The RV-C, unlike other EVs, are resistant to capsid-binding antiviral compounds because the hydrophobic pocket in VP1 is filled with multiple bulky residues. These results define potential molecular determinants for designing antiviral therapeutics and vaccines.
External linksProc Natl Acad Sci U S A / PubMed:27511920 / PubMed Central
MethodsEM (single particle)
Resolution2.79 - 3.16 Å
Structure data

8184

5jzg

EMDB-8184, PDB-5jzg:
CryoEM structure of the native empty particle of a human rhinovirus C
Method: EM (single particle) / Resolution: 3.16 Å

8189

5k0u

EMDB-8189, PDB-5k0u:
CryoEM structure of the full virion of a human rhinovirus C
Method: EM (single particle) / Resolution: 2.79 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • rhinovirus c
KeywordsVIRUS / jelly roll

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