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Structure paper

TitleStructures of mithramycin analogues bound to DNA and implications for targeting transcription factor FLI1.
Journal, issue, pagesNucleic Acids Res., Vol. 44, Page 8990-9004, Year 2016
Publish dateMay 11, 2016 (structure data deposition date)
AuthorsHou, C. / Weidenbach, S. / Cano, K.E. / Wang, Z. / Mitra, P. / Ivanov, D.N. / Rohr, J. / Tsodikov, O.V.
External linksNucleic Acids Res. / PubMed:27587584
MethodsX-ray diffraction
Resolution2 - 3.1 Å
Structure data

PDB-5jvt:
Crystal structure of the DNA binding domain of transcription factor FLI1 in complex with an 11-mer DNA GACCGGAAGTG
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-5jvw:
Crystal structure of mithramycin analogue MTM SA-Trp in complex with a 10-mer DNA AGAGGCCTCT.
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-5jw0:
Crystal structure of mithramycin analogue MTM SA-Phe in complex with a 10-mer DNA AGGGTACCCT
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-5jw2:
Crystal structure of mithramycin analogue MTM SA-Phe in complex with a 10-mer DNA AGGGATCCCT
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-ZN:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-6O6:
Plicamycin, mithramycin analogue MTM SA-Trp

ChemComp-6O7:
Plicamycin, mithramycin analogue MTM SA-Phe / antineoplastic, antibiotic, inhibitor*YM

Source
  • homo sapiens (human)
  • endothia gyrosa (fungus)
  • synthetic construct (others)
Keywordstranscription/dna / transcription / DNA binding / cancer / Ewing sarcoma / transcription-dna complex / dna/antibiotic / anti-cancer agent / transcription factor / minor groove / dna-antibiotic complex / natural product

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