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Structure paper

TitleTermination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes.
Journal, issue, pagesCurr. Biol., Vol. 26, Page 1713-1721, Year 2016
Publish dateApr 20, 2016 (structure data deposition date)
AuthorsDoodhi, H. / Prota, A.E. / Rodriguez-Garcia, R. / Xiao, H. / Custar, D.W. / Bargsten, K. / Katrukha, E.A. / Hilbert, M. / Hua, S. / Jiang, K. ...Doodhi, H. / Prota, A.E. / Rodriguez-Garcia, R. / Xiao, H. / Custar, D.W. / Bargsten, K. / Katrukha, E.A. / Hilbert, M. / Hua, S. / Jiang, K. / Grigoriev, I. / Yang, C.P. / Cox, D. / Horwitz, S.B. / Kapitein, L.C. / Akhmanova, A. / Steinmetz, M.O.
External linksCurr. Biol. / PubMed:27321995
MethodsX-ray diffraction
Resolution2.25 Å
Structure data

PDB-5jh7:
Tubulin-Eribulin complex
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-IMD:
IMIDAZOLE

ChemComp-GOL:
GLYCEROL

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-6K9:
(1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-20-[(2S)-3-amino-2-hydroxypropyl]-21-methoxy-14-methyl-8,15-dimethylidene-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2.1~3,32~.1~3,33~.1~6,9~.1~12,16~.0~18,22~.0~29,36~.0~31,35~]hentetracontan-24-one (non-preferred name) / medication, anticancer*YM

ChemComp-03S:
methanesulfonic acid

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-ACP:
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER / AMP-PCP, energy-carrying molecule analogue*YM

ChemComp-HOH:
WATER

Source
  • rattus norvegicus (Norway rat)
  • gallus gallus (chicken)
  • bos taurus (cattle)
KeywordsCELL CYCLE / CYTOSKELETON / TUBULIN FOLD / MICROTUBULE

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