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Title | Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery. |
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Journal, issue, pages | ACS Omega, Vol. 2, Page 5666-5683, Year 2017 |
Publish date | May 3, 2011 (structure data deposition date) |
Authors | Linciano, P. / Dawson, A. / Pohner, I. / Costa, D.M. / Sa, M.S. / Cordeiro-da-Silva, A. / Luciani, R. / Gul, S. / Witt, G. / Ellinger, B. ...Linciano, P. / Dawson, A. / Pohner, I. / Costa, D.M. / Sa, M.S. / Cordeiro-da-Silva, A. / Luciani, R. / Gul, S. / Witt, G. / Ellinger, B. / Kuzikov, M. / Gribbon, P. / Reinshagen, J. / Wolf, M. / Behrens, B. / Hannaert, V. / Michels, P.A.M. / Nerini, E. / Pozzi, C. / di Pisa, F. / Landi, G. / Santarem, N. / Ferrari, S. / Saxena, P. / Lazzari, S. / Cannazza, G. / Freitas-Junior, L.H. / Moraes, C.B. / Pascoalino, B.S. / Alcantara, L.M. / Bertolacini, C.P. / Fontana, V. / Wittig, U. / Muller, W. / Wade, R.C. / Hunter, W.N. / Mangani, S. / Costantino, L. / Costi, M.P. |
External links | ACS Omega / PubMed:28983525 |
Methods | X-ray diffraction |
Resolution | 1.68 - 2.01 Å |
Structure data | PDB-2yhi: PDB-2yhu: PDB-4wcd: PDB-4wcf: PDB-5izc: |
Chemicals | ChemComp-NAP: ChemComp-W16: ChemComp-DTV: ChemComp-ACT: ChemComp-DTU: ChemComp-DTT: ChemComp-HOH: ChemComp-NDP: ChemComp-WHF: ChemComp-3KH: ChemComp-GOL: ChemComp-3KN: ChemComp-6F4: |
Source |
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Keywords | OXIDOREDUCTASE / SHORT CHAIN DEHYDROGENASE / Thiadiazole derivatives inhibitors / TbPTR1 / Trypanosoma brucei PTR1 / Trypanosoma brucei / pteridine reductase / inhibitor |