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-Structure paper
Title | Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV. |
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Journal, issue, pages | Eur. Biophys. J., Vol. 47, Page 271-290, Year 2018 |
Publish date | Mar 10, 2016 (structure data deposition date) |
Authors | Mickeviciute, A. / Timm, D.D. / Gedgaudas, M. / Linkuviene, V. / Chen, Z. / Waheed, A. / Michailoviene, V. / Zubriene, A. / Smirnov, A. / Capkauskaite, E. ...Mickeviciute, A. / Timm, D.D. / Gedgaudas, M. / Linkuviene, V. / Chen, Z. / Waheed, A. / Michailoviene, V. / Zubriene, A. / Smirnov, A. / Capkauskaite, E. / Baranauskiene, L. / Jachno, J. / Revuckiene, J. / Manakova, E. / Grazulis, S. / Matuliene, J. / Di Cera, E. / Sly, W.S. / Matulis, D. |
External links | Eur. Biophys. J. / PubMed:28975383 |
Methods | X-ray diffraction |
Resolution | 1.8 - 2.1 Å |
Structure data | PDB-5ipz: PDB-5jn8: PDB-5jn9: PDB-5jna: PDB-5jnc: PDB-5ku6: |
Chemicals | ChemComp-ZN: ChemComp-6CC: ChemComp-HOH: ChemComp-AZM: ChemComp-SO4: ChemComp-ACT: ChemComp-GOL: ChemComp-EZL: ChemComp-TOR: ChemComp-6LH: ChemComp-MZM: |
Source |
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Keywords | LYASE / drug design / carbonic anhydrase / benzenesulfonamide / metal-binding / lyase-lyase inhibitor complex / lyase/lyase inhibitor / Inhibitor binding / Zinc / Intrinsic thermodynamics / inhibitor |