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-Structure paper
Title | Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition. |
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Journal, issue, pages | Cancer Res., Vol. 76, Page 2366-2375, Year 2016 |
Publish date | Feb 3, 2016 (structure data deposition date) |
![]() | Brautigam, L. / Pudelko, L. / Jemth, A.S. / Gad, H. / Narwal, M. / Gustafsson, R. / Karsten, S. / Carreras Puigvert, J. / Homan, E. / Berndt, C. ...Brautigam, L. / Pudelko, L. / Jemth, A.S. / Gad, H. / Narwal, M. / Gustafsson, R. / Karsten, S. / Carreras Puigvert, J. / Homan, E. / Berndt, C. / Berglund, U.W. / Stenmark, P. / Helleday, T. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.9 Å |
Structure data | ![]() PDB-5hzx: |
Chemicals | ![]() ChemComp-2GE: ![]() ChemComp-SO4: ![]() ChemComp-GOL: ![]() ChemComp-PEG: ![]() ChemComp-ACT: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / Inhibitor / Complex / MTH1 / TH588 |