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Structure paper

TitleA novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism.
Journal, issue, pagesSci Rep, Vol. 6, Page 39004-39004, Year 2016
Publish dateJan 14, 2016 (structure data deposition date)
AuthorsEyal, Z. / Matzov, D. / Krupkin, M. / Paukner, S. / Riedl, R. / Rozenberg, H. / Zimmerman, E. / Bashan, A. / Yonath, A.
External linksSci Rep / PubMed:27958389
MethodsX-ray diffraction
Resolution3.55 Å
Structure data

PDB-5hl7:
The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with lefamulin
Method: X-RAY DIFFRACTION / Resolution: 3.55 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-62B:
Lefamulin / medication, antibiotic*YM

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-SPD:
SPERMIDINE

ChemComp-EOH:
ETHANOL

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

Source
  • staphylococcus aureus subsp. aureus nctc 8325 (bacteria)
KeywordsRIBOSOME / lefamulin / RNA / antibiotic

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