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Structure paper

TitleStructural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
Journal, issue, pagesImmunity, Vol. 45, Page 737-748, Year 2016
Publish dateJul 14, 2016 (structure data deposition date)
AuthorsZhang, Z. / Ohto, U. / Shibata, T. / Krayukhina, E. / Taoka, M. / Yamauchi, Y. / Tanji, H. / Isobe, T. / Uchiyama, S. / Miyake, K. / Shimizu, T.
External linksImmunity / PubMed:27742543
MethodsX-ray diffraction
Resolution2.2 - 2.6 Å
Structure data

PDB-5gmf:
Crystal structure of monkey TLR7 in complex with guanosine and polyU
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-5gmg:
Crystal structure of monkey TLR7 in complex with loxoribine and polyU
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-5gmh:
Crystal structure of monkey TLR7 in complex with R848
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-GMP:
GUANOSINE

ChemComp-HOH:
WATER

ChemComp-SDL:
2-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-7-prop-2-enyl-1~{H}-purine-6,8-dione

ChemComp-PO4:
PHOSPHATE ION

ChemComp-RX8:
1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol / antivirus*YM

ChemComp-SO4:
SULFATE ION

Source
  • macaca mulatta (Rhesus monkey)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM/RNA / IMMUNE SYSTEM / TLR7 / innate immunity / ssRNA recogniton / IMMUNE SYSTEM-RNA complex

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